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Literature summary for 3.4.23.46 extracted from

  • Dislich, B.; Wohlrab, F.; Bachhuber, T.; Mueller, S.A.; Kuhn, P.H.; Hogl, S.; Meyer-Luehmann, M.; Lichtenthaler, S.F.
    Label-free quantitative proteomics of mouse cerebrospinal fluid detects beta-site APP cleaving enzyme (BACE1) protease substrates in vivo (2015), Mol. Cell. Proteomics, 14, 2550-2563 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.46

Application

Application Comment Organism
medicine the enzyme is a major drug target in Alzheimer's disease Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P56818
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebrospinal fluid
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Mus musculus ?
-
 ?
APLP1 + H2O
-
 Mus musculus ?
-
 ?
CHL1 + H2O
-
 Mus musculus ?
-
 ?
contactin-2 + H2O
-
 Mus musculus ?
-
 ?
ectonucleotide diphosphatase 5 + H2O
-
 Mus musculus ?
-
 ?
plexin domain-containing 2 + H2O
-
 Mus musculus ?
-
 ?
receptor-type tyrosine-protein phosphatase N2 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Mus musculus
beta-site APP cleaving enzyme 1
-
 Mus musculus